Babraham Bioscience Technologies
Babraham Research Campus - Cambridge - UK
Alpha Biologics Ltd
Alpha Biologics is a cGMP contract manufacturer of mammalian cell secreted proteins for use in pre-clinical and Phase 1 & Phase 2 clinical trials. Their cGMP facility is based on the Penang Biotech Park in the state of Penang, Malaysia and is managed by staff with extensive experience in the cGMP contract manufacturing. Alpha’s process development group is led by our highly skilled team, all of whom have cGMP experience, based in Cambridge, England. Alpha provide services from cell line generation, including stability and optimisation studies, GMP cell banking, upstream and downstream manufacturing process development and cGMP manufacture for clinical trials in Europe, North America and Asia.
Antitope Limited
Antitope is pioneering a new generation of immunogenicity testing and protein engineering technologies. Their mission is to apply these technologies to create improved non-immunogenic biologics.
Bicycle Therapeutics Limited
Bicycle Therapeutics is a newly formed biotechnology company developing a novel technology for the creation of a new generation of biotherapeutics. Bicycle technology utilises biological selection techniques to select and optimise peptides with high binding affinities which are constrained by an organo-chemical scaffold. This enables the creation of novel molecules which combine the desirable features of small molecules and biopharmaceuticals. The technology is based on the work performed at the MRC Laboratory of Molecular Biology in Cambridge by the scientific founders of the company, Prof. Christian Heinis and Prof. Sir Gregory Winter.
Cell Guidance Systems Ltd
Cell Guidance Systems develops and manufactures reagents for life science research and biomanufacturing. The Company focuses on stem cells and has developed two key technology platforms. The first, Pluripro® defined media and substrate reagents, allow for confluent culture of pluripotent cells. Pluripro® technology simplifies and significantly reduces the cost of human ES and iPS cell culture. The Company’s second technology platform, STAR growth factors, uses a proprietary modification process that addresses cost and performance issues for growth factors. The modified growth factors develop orders-of-magnitude improvement in biological activity. Our initial focus is on the commercial launch of growth factors that will address cost and performance issues currently hampering the development of stem cell therapeutics.
Convergence Pharmaceuticals Ltd
Convergence Pharmaceuticals is focused on the development of novel analgesics with commercially attractive efficacy, responder-rate and side effect profiles. The Company is an independent biotechnology company which was formed in October 2010 following the acquisition of clinical assets from GlaxoSmithKline. Convergence Pharmaceuticals’ pipeline of differentiated clinical-stage compounds targets the points of convergence in chronic pain signaling through modulation of specific ion-channels. The Company is well funded and raised $35.4 million (£22.4 million) in Series A financing from a syndicate of leading European and US VCs. Convergence Pharmaceuticals’ management team is led by Clive Dix, Chief Executive Officer (ex PowderMed, PowderJect, Glaxo Wellcome), Simon Tate, Chief Scientific Officer (ex GSK) and Brenda Reynolds, Chief Operating Officer (ex PowderMed, PowderJect, Pfizer). The team collectively has extensive experience in leading successful biotech ventures and in drug development.
Crescendo Biologics Ltd
Crescendo Biologics will apply highly innovative antibody fragment technologies to the development of new targeted therapeutics. The Crescendo transgenic mouse platform under development has the potential to rapidly and predictably generate high-affinity human heavy chain antibodies that readily yield VH fragments that have no requirement for humanisation. This is combined with a powerful in vitro ribosome display technology which offers significant advantages over existing approaches in antibody optimisation. VH fragments provide great flexibility as a starting point for the development of new targeted therapeutics combining the specificity and binding affinity of antibodies with certain desirable characteristics of small molecules. Crescendo’s technologies were invented by scientists at the Babraham Institute, Cambridge (UK). The Company has raised £4.5 million in seed funding from leading life sciences investors, Sofinnova Partners with Aitua, Avlar BioVentures and the Rainbow Seed Fund also participating.
DiagNodus Ltd
DiagNodus is a biomedical company, the principal direction of which is the development of a new non-invasive approach to colorectal cancer screening based upon introduction of an innovative rapid ‘point of care’ test. The company works on several versions of the product, some of which may also be applicable for non-invasive testing for a wider range of gastrointestinal conditions aiming improved disease detection, differential diagnosis and monitoring.
Discerna Ltd
Discerna is an emerging company developing innovative protein technologies for application to the discovery and analysis of biopharmaceuticals. Recognising the commercial potential of recombinant protein-based products, particularly antibodies, Discerna has created a platform of technologies that both improve upon and complement established methods of developing biopharmaceuticals. Proprietary technologies include ribosome display and in-situ protein arrays.
Eagle Genomics Ltd
Eagle Genomics is a bioinformatics services and software company with over 20 years combined experience of developing and supporting bioinformatics databases and software in institutes around the world, such as EBI, Sanger Institute, Genoscope, CSHL, AgResearch, GIS. So it is no surprise we have unique expertise in accessing, as well as integrating, open-source bioinformatics platforms into tool-kits that our clients tell us are reliable, easy-to-use and cost-effective.
We work with commerical and academic organisations, large or small, requiring technical solutions to their clinical and non-clinical bioinformatics challenges using any combination of public and/or private data.
Our mission is to position ourselves as the leading intermediary between academia and industry for bioinformatics applications and combine the best of both worlds for our clients.
Immunobiology Ltd
ImmunoBiology Limited (ImmBio) is a biotechnology company developing the next generation of vaccines for the prevention and treatment of infectious diseases by applying its proprietary HspC™ vaccine technology platform to development of breakthrough products.
Innova Biosciences Ltd
Innova Biosciences is building a portfolio of innovative reagents and kits for high throughput drug screening. The company is currently developing a universal kinase assay that will work with any combination of enzyme and substrate, and on multiple instrument platforms. The system will effectively eliminate assay development work for kinase targets and thus greatly accelerate kinase-based drug discovery project.
Kymab Ltd
Kymab is using embryonic stem cell technology to develop its Kymouse™ platform, which encompasses the entire diversity of the B lymphocyte component of the human immune system. This will allow the discovery of highly selective, potent and well-tolerated monoclonal antibody-based biopharmaceuticals. These new drugs will include best-in-class antibodies directed against clinically precedented drug targets and first-in-class drugs against novel targets.
Mission Therapeutics Ltd
MISSION Therapeutics is a specialist pharmaceutical company whose aim is to translate new molecular understandings of human cell biology into drugs that will markedly improve the management of life-threatening diseases, particularly cancer.
MISSION Therapeutics holds and will maintain world-leadership in DNA repair and associated molecular pathways. The company will use its knowledge and proven expertise in targeting these pathways for small-molecule drug discovery to develop new therapeutic agents with wide market potential. These drugs will mainly target "Achilles heels" of diseased tissues by exploiting the concept of synthetic-lethality.
Mission Therapeutics was founded by Professor Steve Jackson, a world expert on the DNA damage response. Steve is Senior Group Leader and Head of Cancer Research UK Laboratories in the Gurdon Institute, Cambridge University and is the University's Frederick James Quick Professor of Biology. For information on his research, see http://www.gurdon.cam.ac.uk/~jacksonlab/
NorayBIO
NorayBio is a bioinformatics company that supports the life sciences sector: biotechnology, biomedicine and biopharmaceuticals, developing new software solutions. We specialise in software for Biobanks, Animal Research and biotechnology companies and laboratories.
Company headquarters are based in Bilbao, north of Spain, and currently the company has three sales offices in Europe, in Cambridge, Lyon and Turin, with the aim to support foreign customers and open new markets. NorayBio does also have a strategic alliance with the British Aston Pharma as commercial agent in the UK.
NorayBio is Microsoft Certified Partner and part of Oracle Partner Network, as well as
ISO 9001:2008 accredited.
Phico Therapeutics Ltd
Phico Therapeutics is an early stage biotechnology company developing a novel platform technology to produce therapeutic anti-bacterials active against all species of bacteria. Initial products in development are targeted at antibiotic resistant bacteria, including MRSA.
Population Genetics Technologies Ltd
To develop technology invented by Nobel Laureate, Sydney Brenner, for obtaining sequence information from thousands of genomes simultaneously. Applications include the discovery of genetic variations affecting common diseases and the development of safer more effective drugs. Current technologies can only analyse one genome at a time. The Wellcome Trust has granted £1.1m to begin development of the technology, pending receipt of additional Venture Capital investments. The IP and related patent applications underlying the technology were licensed from Compass Genetics LLC, a partnership formed by Drs Sydney Brenner, Sam Eletr and Philip Goelet.
Proximagen Ltd
Proximagen Limited is focused on the development and commercialisation of novel therapeutics for diseases of the CNS, neuroinflammation/inflammation and oncology. The Company is developin a broad pipeline of drug candidate programmes and has plans for substantial future growth through acquiring and developing innovative drug candidate programmes. The Company's strong balance sheet makes Proximagen one of the best capitalised biotechnology companies in the UK.
Rapid Biosensor Systems Ltd
Rapid Biosensor Systems Ltd is an innovative technology and business development Company with experience in development and commercial exploitation of IPR for rapid screening infectious diseases. Their skills are in business management, technology development, photonics, biochemistry, and medical consultancy. RBS can assist with the concepts right through to production. Their first product is a "Breathalyser" style device for screening Tuberculosis (TB) at the Point-of-Test. The product is designed to be small, rugged, simple to use and low cost. Furthermore, the device minimizes both the need for training and the risk of infection of the operator.
Recombinant Antibody Technology Ltd
Recombinant Antibody Technology Ltd. is specializing in the generation of large recombinant DNA constructs using YAC and BAC technologies. Currently, the company is working with Open Monoclonal Technology, Inc., a US based biotechnology company, on the generation of recombinant immunoglobulin loci for the generation of genetically engineered rats expressing antibodies with fully human idiotypes.
Senexis Ltd
Senexis is developing novel inhibitors of amyloidosis: a fundamental mechanism of toxicity associated with twenty ageing-related diseases. We have identified the most potent and selective amyloidosis inhibitors known and our drug candidates fro Alzheimer’s disease have already shown pre-clinical efficacy in models of memory and learning. Senexis is building a pipeline of drug candidates for the treatment of Alzheimer’s and Parkinson’s diseases, as well as diabetes. It is then planned to enter the clinic with at least one of our drug candidates, while partnering others.
StemCells, Inc.
SCS is a global biotechnology company focused on the provision of stem cells and technology for biopharmaceutical research and clinical applications. SCS’ business strategy is accelerating product development by working in partnership with academia and industry in developing cellular products and technologies. SCS’ core business objective is to develop proprietary stem cell products for the treatment of neurological and muscular disease and injury.
Synome Ltd
Synome offers a versatile battery of in vitro electrophysiological tests. Our aim is to accelerate the discovery of novel drugs for treatment of mental disorders by utilising multiplexing capabilities of multi-electrode arrays technology. Synome’s scientists have experience from large-scale electrophysiological screening of more than 50 transgenic mouse lines. Synome is a member of 4 academic EU Framework Programme 7 projects (EUROSPIN, SynSYS, GENCODYS, PharMEA) aimed at the elucidation of roles of synaptic proteins in brain disorders. We also aim to establish an in-house pipeline of drug leads in the CNS area.
Total Scientific Ltd
Total Scientific is a contract research organisation with experience in all aspects of biomarker research, from identification of the biomarker using 'omics technology through independent assay design, development, optimisation and validation to multi-site clinical studies designed to validate or test biomarkers. However, in addition to these biomarker-related activities we can provide a large range of scientific expertise and consultancy relating to data management and biostatistics, multiplex technology and immunology.
TwistDx Ltd
Twist Dx Ltd is a company developing proprietary technology in the area of DNA amplifications and sequencing. Their novel approach to acquiring sequences from individual DNA strands, Direct Nucleic Acid Sequencing (DNAS), will permit the analysis of entire genomes in only days or hours. Twist Dx Ltd is also exploring novel and improved ways of amplifying target DNA sequences for applications in the life sciences.
UroSens Ltd
UroSens is developing a simple and highly sensitive test for bladder cancer based on detection of the marker protein Mcm5 in patients' urine. The test will be used in differential diagnosis in patients with haematuria or other symptoms and for surveillance and disease monitoring. There are over 140,000 new cases of bladder cancer a year in Europe and the US and over a million people live with the disease. The condition has a high recurrence rate, therefore frequent post-treatment testing is required. UroSens' test addresses the key disadvantages of invasiveness and high cost associated with bladder endoscopy, the current gold standard diagnostic method.